We work at the intersection of several different disciplines, including cancer biology, cancer-immune interactions, and RNA processing. Our broad goal is to discover novel molecular mechanisms that govern cancer initiation, progression, or response to therapy. Some areas of current interest are:

• functional consequences of splicing factor mutations
• mechanisms of cancer immune evasion
• isoform-level, high-throughput genetic screens

We use a diverse toolkit, including functional genomics, mouse modeling, computational and statistical analyses, and RNA biochemistry.

We are located at the Fred Hutchinson Cancer Center in Seattle, Washington.